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100 µl

Ref. REV-31-1200-00-R100
RevMab

photos non contractuelles

Neuf 493.00 H.T.

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Détails Produit

Product description: Recombinant Antibody. This antibody reacts to human CD5. Applications: WB, IHC. Source: Rabbit. Liquid. 50% Glycerol/PBS with 1% BSA and 0.09% sodium azide. CD5 is a 67 kDa human T-lymphocyte single-chain transmembrane glycoprotein, also known as Leu-1, Ly-1 and T1. It is a member of the scavenger receptor superfamily found on T cells, thymocytes, B cell subsets, chronic B lymphocytic leukemia (B-Cells), peripheral blood dendritic cells and on many T-cell leukemias and lymphomas. CD5 also reacts with a subpopulation of activated B-cells and may act as a receptor in regulating T-cell proliferation. CD5 modulates T and B cell receptor signaling, thymocyte maturation and T-B cell interactions upon binding to ligands such as CD72. CD5 is found on 95% of thymocytes and 72% of peripheral blood lymphocytes. In lymph nodes, the main reactivity is observed in T cell areas. CD5 is expressed by many T cell leukemia, lymphomas and activated T cells. Diseases associated with CD5 dysfunction include thymus cancer and Richter's Syndrome.

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