anti-cGMP, Rabbit Monoclonal (RM467)

Product description: Recombinant Antibody. RM467 reacts to cGMP (Cyclic Guanosine Monophosphate). No cross-reactivity with other cyclic nucleotide or nucleoside phosphate. Isotype: Rabbit IgG. Immunogen: KLH-conjugated cGMP. Applications: ELISA. Liquid. 50% Glycerol/PBS with 1% BSA and 0.09% sodium azide. Cyclic guanosine monophosphate (cGMP) serves as a second messenger in a manner similar to that observed with cAMP. Peptide hormones, such as the natriuretic factors, activate receptors that are associated with membrane-bound guanylate cyclase (GC). Receptor activation of GC leads to the conversion of GTP to cGMP. Nitric oxide (NO) also stimulates cGMP production by activating soluble GC, perhaps by binding to the heme moiety of the enzyme. Similar to cAMP, cGMP mediates most of its intracellular effects through the activation of specific cGMP dependent protein kinases (PKG).

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