anti-Collagen Type 1 (3/4 fragment), pAb

PRODUIT SUPPRIME

VOIR LE REMPLACEMENT : AG-25T-0116-C050

Product description: The proteolysis of collagens plays an important role in numerous physiological and pathological situations such as morphogenesis, wound healing, arthritis, arteriosclerosis and tumor metastasis. Triple helical type I collagens are made up of two alpha1 (I) and one alpha2 (I) chains, and are found in skin, tendon, ligament and interstitial tissues. Due to their fibrillary structure native collagens are resistant to most proteases. They are substrates for certain matrix metalloproteinases (MMPs), which constitute a family of zinc-dependent enzymes catalyzing the degradation of extracellular matrix components. Initial MMP-8 dependent cleavage of collagen into the characteristic ¾ and ¼ fragments has been shown to enable MMP-9 diffusion along the protein helix with preferential binding to the collagen ¾ fragment tail. Finally, untwisting of the helix end results in the local denaturation of the triple helical structure.

Alternate Names/Synonyms: COL1; alpha-1 Type I Collagen

Product Type: Polyclonal Antibody

Immunogen: Synthetic peptide (human sequence) corresponding to the C-terminal end of the N-terminal three quarter collagen fragment (Col1 ¾).

Applications: ICC

Species Crossreactivity: Bovine, Cat, Cow, Dog, Hamster, Human, Monkey, Mouse, Pig, Rat, Sheep

Specificity: Recognizes rat and bovine collagen type 1 cleavage site. Based on sequence identity should also recognize human, mouse, guinea pig, dog, cat, donkey, pig, cow, sheep and chicken collagen type 1.

Purity: Antigen affinity purified.

Concentration: 200µg/ml.

Formulation: Liquid. In PBS with 1 mg/ml BSA and 0.02% sodium azide.

Short Term Storage: +4°C

Long Term Storage: -20°C

Shipping: BLUE ICE

Use & Stability: Stable for at least 1 year after receipt when stored at -20°C.

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