anti-Dityrosine [DT], mAb (1C3)

Product description: Tyrosine is one of the major targets of protein oxidation. Dityrosine (DT) is known to be formed when tyrosine is damaged by free radicals, such as reactive oxygen species (ROS), metal-catalyzed oxidation, ultraviolet irradiation, and peroxidases. Dityrosine has been found in atherosclerotic lesions, and lipofuscin of pyramidal neurons of aged human brains. Dityrosine is a specific biomarker for protein oxidation. Dityrosine is reported to exist in various tissues and was also recently detected in urine samples. It is expected to be a novel protein oxdation marker, which is non-invasively detectable.

Product Type: Monoclonal Antibody

Clone: 1C3

Isotype: Mouse IgG2akappa

Immunogen: 3-(p-hydroxyphenyl) propionic acid dimer-conjugated keyhole limpet hemocyanin.

Applications: ELISA, IHC, WB

Species Crossreactivity: All, Human

Specificity: Recognizes free dityrosine, 3-(p-hydroxyphenyl) propionic acid dimer, dityrosine-BSA conjugate, and dityrosine in protein or peptides. Does not cross-react with nitrotyrosine, chlorotyrosine, aminotyrosine, phosphotyrosine, tyrosine, 3-(p-hydroxyphenyl) propionic acid, phenylalanine, 3,4-dihydroxyphenylacetic acid (DOPA).

Formulation: Lyophilized. Contains 10mM PBS (pH7.4).

Long Term Storage: -20°C

Shipping: BLUE ICE

Use & Stability: Stable for at least 3 years after receipt when stored at -20°C.

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