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100 µg

Ref. AG-20B-0050-C100
ADIPOGEN LIFE SCIENCES

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Neuf 330.00 297.00 H.T.

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Détails Produit

Product description: Monoclonal Antibody. Recognizes mouse IL-1alpha. Isotype: Mouse IgG. Clone: Bamboo-1. Applications: ELISA, WB. Liquid. In PBS containing 10% glycerol and 0.02% sodium azide. The most prominent members of the interleukin-1 (IL-1) superfamily are IL-1alpha and IL-1beta. They lack a signal peptide and are secreted by an unconventional, endoplasmic reticulum-Golgi-independent mechanism. IL-1alpha was reported to be more widely and constitutively expressed and has intracellular functions, but also acts locally in a membrane-bound form by activating IL-1R1. Additionally, passive release of IL-1alpha upon cell death can trigger a sterile inflammatory response to dying cells. The cleavage of IL-1alpha is not mediated by caspase-1 and is not required for binding to IL-1R1. Recently it has been observed that all activators of the inflammasome NLRP3/NALP3 induce the simultaneous secretion of IL-1alpha and IL-1beta. Although most activators fully rely on the inflammasome for IL-1alpha secretion, some induce the processing and secretion of IL-1alpha in an inflammasome-independent manner.

Alternate Names/Synonyms: Interleukin-1alpha

Product Type: Monoclonal Antibody

Clone: Bamboo-1

Isotype: Mouse IgG

Immunogen: Recombinant mouse mature IL-1alpha.

Applications: ELISA, WB

Species Crossreactivity: Mouse

Specificity: Recognizes mouse IL-1alpha.

Purity: >95% (SDS-PAGE)

Concentration: 1mg/ml

Formulation: Liquid. In PBS containing 10% glycerol and 0.02% sodium azide.

Short Term Storage: +4°C

Long Term Storage: -20°C

Shipping: BLUE ICE

Use & Stability: Stable for at least 1 year after receipt when stored at -20°C.

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