anti-IL-33 (human), mAb (IL33305B)

Product description: Monoclonal Antibody. Recognizes human IL-33. Does not cross-react with mouse IL-33. Isotype: Mouse IgG2akappa. Clone: IL33305B. Applications: ELISA, FUNC (Blocking), IHC, IP, WB. Liquid. 0.2µm-filtered solution in PBS, pH 7.4. Contains no preservatives. Interleukin-33 (IL-33; HF-NEV; IL-1F11), a member of the IL-1 family of cytokines, is expressed by many cell types following pro-inflammatory stimulation and is thought to be released on cell lysis. The 30kDa human IL33 is converted by CASP1 to a 18kDa protein. IL33 binds to and signals through ST2 (IL1R1) and its stimulation recruits MYD88, IRAK, IRAK4, and TRAF6, followed by phosphorylation of ERK1 (MAPK3)/ERK2 (MAPK1), p38(MAPK14), and JNK. The ability of IL-33 to target numerous immune cell types, like Th2-like cells, mast cells, and B1 cells, and to induce cytokine and chemokine production underlines its potential in influencing the outcome of a wide range of diseases, such as arthritis, asthma, atopic allergy & anaphylaxis, cardiovascular disease/atherosclerosis, nervous system diseases, and sepsis.

Alternate Names/Synonyms: Interleukin-33; IL-1F11; NF-HEV

Product Type: Monoclonal Antibody

Clone: IL33305B

Isotype: Mouse IgG2akappa

Immunogen: Recombinant human IL-33.

Applications: ELISA, FUNC (Blocking), IHC, IP, WB

Species Crossreactivity: Human

Specificity: Recognizes human IL-33. Does not cross-react with mouse IL-33.

Concentration: 1mg/ml

Formulation: Liquid. 0.2µm-filtered solution in PBS, pH 7.4. Contains no preservatives.

Short Term Storage: +4°C

Long Term Storage: -20°C

Shipping: BLUE ICE

Use & Stability: Stable for at least 1 year after receipt when stored at -20°C.

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Literature References: Inhibition of interleukin-33 signaling attenuates the severity of experimental arthritis: G. Palmer, et al.; Arthritis & Rheum. 60, 738 (2009) | Transcriptomic and genetic studies identify IL-33 as a candidate gene for Alzheimer's disease: J. Chapuis, et al.; Mol. Psychiatry 14, 1004 (2009) (Supplement Information) | Interleukin-33 is biologically active independently of caspase-1 cleavage: D. Talabot-Ayer, et al.; JBC 284, 19420 (2009)