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100 µg

Ref. AG-25A-0045-C100
ADIPOGEN LIFE SCIENCES

photos non contractuelles

Neuf 150.00 135.00 H.T.

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Détails Produit

Product description: Polyclonal Antibody. Recognizes human IL-33. Detects a band of ~18kDa by Western blot. Source: Rabbit. Applications: ELISA, IHC, WB. Liquid. 0.2µm-filtered solution in PBS, pH 7.4. Contains no preservatives. Interleukin-33 (IL-33; HF-NEV; IL-1F11), a member of the IL-1 family of cytokines, is expressed by many cell types following pro-inflammatory stimulation and is thought to be released on cell lysis. The 30kDa human IL33 is converted by CASP1 to a 18kDa protein. IL33 binds to and signals through ST2 (IL1R1) and its stimulation recruits MYD88, IRAK, IRAK4, and TRAF6, followed by phosphorylation of ERK1(MAPK3)/ERK2(MAPK1), p38(MAPK14), and JNK. The ability of IL-33 to target numerous immune cell types, like Th2-like cells, mast cells, and B1 cells, and to induce cytokine and chemokine production underlines its potential in influencing the outcome of a wide range of diseases, such as arthritis, asthma, atopic allergy & anaphylaxis, cardiovascular disease/atherosclerosis, nervous system diseases, and sepsis.

Alternate Names/Synonyms: Interleukin-33; IL-1F11; NF-HEV

Product Type: Polyclonal Antibody

Immunogen: Recombinant human IL-33.

Applications: ELISA, IHC, WB

Species Crossreactivity: Human

Specificity: Recognizes human IL-33. Detects a band of ~18kDa by Western blot.

Concentration: 1mg/ml

Formulation: Liquid. 0.2µm-filtered solution in PBS, pH 7.4. Contains no preservatives.

Short Term Storage: +4°C

Long Term Storage: -20°C

Shipping: BLUE ICE

Use & Stability: Stable for at least 6 months after receipt when stored at -20°C.

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Literature References: IL-33, the IL-1-like cytokine ligand for ST2 receptor, is a chromatin-associated nuclear factor in vivo: V. Carriere et al.; PNAS 104, 282 (2007) | An IL-1 cytokine member, IL-33, induces human basophil activation via its ST2 receptor: M. Suzukawa, et al.; J. Immunol. 181, 5981 (2008)