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1 Mg

Ref. AG-20B-0008PF-M001
ADIPOGEN LIFE SCIENCES

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Neuf 1200.00 H.T.
en stock

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Détails Produit

Product description: Monoclonal Antibody. Recognizes mouse LTbetaR. Isotype: Rat IgG2a. Clone: 4H8 WH2. Applications: FACS, FUNC (Blocking). Liquid. In PBS containing 10% glycerol. The LTbetaR activates two different NF-kappaB pathways that lead to distinct patterns of gene induction, including selected chemokines and the cytokine BAFF, which is essential for the survival of mature B lymphocytes. LTbetaR activates the classical NF-kappaB (relA/p50) pathway, like the type 1 TNF receptor (TNFR1), that regulates proinflammatory genes, like the chemokine MIP1beta. However, LTbetaR, unlike TNFR1, also activates the processing of p100 to form RelB/p52 complexes, which activate genes involved in lymphoid organ formation and lymphocyte survival.

Alternate Names/Synonyms: Lymphotoxin-beta Receptor; Tumor Necrosis Factor Receptor 2 Related Protein; Tumor Necrosis Factor C Receptor; Tumor Necrosis Factor Receptor Superfamily Member 3; TNFRSF3

Product Type: Monoclonal Antibody

Clone: 4H8 WH2

Isotype: Rat IgG2a

Immunogen: Recombinant mouse LTbetaR (cysteine-rich region/aa 31-221).

Labels - Conjugates: Preservative Free

Applications: FACS, FUNC (Blocking)

Species Crossreactivity: Mouse

Specificity: Recognizes mouse LTbetaR.

Purity: >95% (SDS-PAGE)

Concentration: 1mg/ml

Formulation: Liquid. In PBS containing 10% glycerol.

Short Term Storage: +4°C

Long Term Storage: -20°C

Shipping: BLUE ICE

Use & Stability: Stable for at least 1 year after receipt when stored at -20°C.

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Literature References: The lymphotoxin-beta receptor induces different patterns of gene expression via two NF-kappaB pathways: E. Dejardin, et al.; Immunity 17, 525 (2002) | Lymphotoxin-mediated regulation of gammadelta cell differentiation by alphabeta T cell progenitors: B. Silva-Santos, et al.; Science 307, 925 (2005) | LTbetaR Signaling Induces Cytokine Expression and Up-Regulates Lymphangiogenic Factors in Lymph Node Anlagen. M.F. Vondenhoff, et al.; J. Immunol. 182, 5439 (2009)