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30 µg

Ref. JAI-MMG-030N
JAICA

photos non contractuelles

Neuf 662.00 H.T.
en stock

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Détails Produit

Product description: Monoclonal Antibody. Recognizes MG-modified proteins (especially Argpyrimidine). Frozen liquid. Contains 10mM PBS, 0.1% NaN3 and 0.5% BSA. Methylglyoxal (MG), an endogenous metabolite that increases in diabetes and is a common intermediate in the Maillard reaction (glycation), reacts with proteins and forms advanced glycation end products (AGE). MG reacts with arginine residue in protein and forms numerous numbers of adducts, such as argpyrimidine.

Alternate Names/Synonyms:

Product Type: Monoclonal Antibody

Clone: 3C

Isotype: Mouse IgG2a

Immunogen: MG-modified keyhole-lympet hemocyanine.

Applications: IHC, WB

Species Crossreactivity: All, Human

Specificity: Recognizes MG-modified proteins (especially Argpyrimidine).

Formulation: Frozen liquid. Contains 10mM PBS, 0.1% NaN3 and 0.5% BSA.

Short Term Storage: +4°C

Long Term Storage: -20°C

Shipping: BLUE ICE

Use & Stability: Stable for at least 3 years after receipt when stored at -20°C.

Lien vers la Fiche Technique

Literature References: Protein modification by a Maillard reaction intermediate methylglyoxal. Immunochemical detection of fluorescent 5-methylimidazolone derivatives in vivo: K. Uchida, et al.; FEBS Lett. 410, 313 (1997) | Methylglyoxal Modification of Protein -Chemical and Immunochemical Characterization of Methylglyoxal-Arginine Adduct: T. Oya, et al.; J. Biol. Chem. 274, 18492 (1999) | Advanced glycation and lipidoxidation of the peritoneal membrane: respective roles of serum and peritoneal fluid reactive carbonyl compounds: T. Miyata, et al.; Kidney Int. 58, 425 (2000) | Argpyrimidine, a blue fluorophore in human lens proteins: high levels in brunescent cataractous lenses: P.S. Padayatti, et al.; Invest. Ophthalmol. Vis. Sci. 42, 1299 (2001) | High concentrations of glucose induce synthesis of argpyrimidine in retinal endothelial cells: P.S. Padayatti, et al.; Curr. Eye Res. 23, 106 (2001) | Curcumin Inhibits ROS Formation and Apoptosis in Methylglyoxal- Treated Human Hepatoma G2 Cells: W.-H. Chan, et al.; Ann. N.Y. Acad. Sci. 1042, 372 (2005)