anti-MUC-1 (Mucin-1) (human), Rabbit Monoclonal (RM489)

Product description: Recombinant Antibody. This antibody reacts to human Muc-1 (Mucin-1). Source: Rabbit. Isotype: Rabbit IgG. Immunogen: A peptide corresponding to the cytoplasmic domain of human Mucin-1. Applications: IHC, WB. MUC1 is a large cell surface mucin glycoprotein expressed by most glandular and ductal epithelial cells and some hematopoietic cell lineages. MUC1 is a transmembrane glycoprotein with a large mucin-like extracellular domain that matures through several intermediate forms generated by proteolysis, and sequential addition and processing of numerous O-linked glycans that are heavily sialylated. MUC1 is highly polymorphic and each allele encodes a product that contains a different number of repeats (between 30 and 90) leading to large differences in molecular weight of the protein. MUC1 is expressed on most secretory epithelium, including mammary gland and some hematopoietic cells, and is expressed abundantly in >90% breast carcinomas and metastases. Overexpression, aberrant intracellular localization, and changes in glycosylation of the MUC1 protein have been associated with carcinomas.

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