anti-Musashi 2 (human), Rabbit Monoclonal (RM422)

Product description: Recombinant Antibody. This antibody RM422 reacts to human Musashi 2. This antibody may also react to mouse or rat Musashi 2, as predicted by immunogen homology. Application: IHC, WB . Source: Rabbit. Liquid. 50% Glycerol/PBS with 1% BSA and 0.09% sodium azide. Musashi 2, also known as MSI2 or MSI2H, is a 328 aa protein that localizes to the cytoplasm and contains two RRM (RNA recognition motif) domains. Expressed ubiquitously at low levels, MSI2 functions as an RNA binding protein that, by regulating the expression of target mRNAs, is thought to play a role in the proliferation and maintenance of stem cells within the central nervous system. MSI2 is subject to posttranslational phosphorylation and is upregulated in response to brain injury, suggesting a role in healing and brain tissue regeneration. Chromosomal aberrations involving the MSI2 gene are associated with the progression of chronic myeloid leukemia.

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