anti-Nitrotryptophan (NW), mAb (117C)

Product description: Reactive nitrogen species (RNS) are formed in a variety of diseases such as atherosclerosis, inflammation, cancer and neurodegenerative diseases. Peroxinitrite (ONOO-) is known as a potent biological oxidant, which is formed via very fast reaction between nitric oxide (NO) and superoxide (O2-). Peroxinitrite can induce nitration of aromatic amino acids such as Tyr, Trp, Phe and His, which results in modulation of protein functions. To date, 6-nitrotryptophan (6-NO2-Trp) is shown to be one of the most stable and major peroxynitrite-modified amino acids, and growing evidences suggest that nitrotryptophan may play a significant role in the cellular regulation under nitrosative stress. This antibody is suitable for immunohistochemistry, western blotting and ELISA and may provide a powerful tool for the investigation of nitrosative stress inside living bodies.

Product Type: Monoclonal Antibody

Clone: 117C

Isotype: Mouse IgG1kappa

Immunogen: 6-Nitrotryptophan modified Keyhole Limpet Hemocyanin (KLH).

Applications: IHC, WB

Species Crossreactivity: All, Human

Specificity: Recognizes 6-Nitrotryptophan.

Concentration: 100µg/ml of IgG in 10mM PBS (pH 7.4).

Formulation: Lyophilized.

Long Term Storage: -20°C

Shipping: BLUE ICE

Use & Stability: Stable for at least 3 years after receipt when stored at -20°C.

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