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AVANTI POLAR LIPIDS , CYGNUS , LARODAN , ADIPOGEN , MYBIOSOURCE , SERVA NORDMARK, BIOWORLD, EDGEBIO , PANREAC APPLICHEM
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Product description: The inflammasome is a multiprotein complex that mediates the activation of caspase-1, which promotes, amongst others, the secretion of the proinflammatory cytokines interleukin (IL)-1beta and IL-18. Members of the Nod-like receptor family, including NLRP3/NALP3, are critical components of the inflammasome that link danger-signals to caspase-1 activation. Defects in NLRP3 are the cause of familial cold autoinflammatory syndrome type 1 (FCAS1), Muckle-Wells syndrome (MWS) and of chronic infantile neurologic cutaneous and articular syndrome (CINCA).
Alternate Names/Synonyms: NACHT-, LRR- and PYD-containing Protein 3; NLRP3; Cryopyrin; Cold Autoinflammatory Syndrome 1 Protein
Product Type: Monoclonal Antibody
Clone: Cryo-2
Isotype: Mouse IgG2b
Immunogen: Recombinant mouse NLRP3/NALP3 (pyrin domain/aa 1-93).
Applications: IHC, IP, WB
Species Crossreactivity: Human, Mouse
Specificity: Recognizes mouse and human NLRP3/NALP3.
Concentration: 1mg/ml
Formulation: Liquid. In PBS containing 10% glycerol and 0.02% sodium azide.
Long Term Storage: -20°C
Shipping: BLUE ICE
Use & Stability: Stable for at least 1 year after receipt when stored at -20°C.
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