anti-NLRP3/NALP3, mAb (Cryo-2)

Product description: The inflammasome is a multiprotein complex that mediates the activation of caspase-1, which promotes, amongst others, the secretion of the proinflammatory cytokines interleukin (IL)-1beta and IL-18. Members of the Nod-like receptor family, including NLRP3/NALP3, are critical components of the inflammasome that link danger-signals to caspase-1 activation. Defects in NLRP3 are the cause of familial cold autoinflammatory syndrome type 1 (FCAS1), Muckle-Wells syndrome (MWS) and of chronic infantile neurologic cutaneous and articular syndrome (CINCA).

Alternate Names/Synonyms: NACHT-, LRR- and PYD-containing Protein 3; NLRP3; Cryopyrin; Cold Autoinflammatory Syndrome 1 Protein

Product Type: Monoclonal Antibody

Clone: Cryo-2

Isotype: Mouse IgG2b

Immunogen: Recombinant mouse NLRP3/NALP3 (pyrin domain/aa 1-93).

Applications: IHC, IP, WB

Species Crossreactivity: Human, Mouse

Specificity: Recognizes mouse and human NLRP3/NALP3.

Concentration: 1mg/ml

Formulation: Liquid. In PBS containing 10% glycerol and 0.02% sodium azide.

Long Term Storage: -20°C

Shipping: BLUE ICE

Use & Stability: Stable for at least 1 year after receipt when stored at -20°C.

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