anti-p70S6K (human), Rabbit Monoclonal (RM438)

Product description: Recombinant Antibody. This antibody reacts to human p70S6K. Apllication: IHC, WB. Liquid. 50% Glycerol/PBS with 1% BSA and 0.09% sodium azide. The p70S6 kinase (p70 Ribosomal Protein S6 Kinase, p70S6K) is a 70kDa member of the ribosomal S6 kinase (RSK) family of serine/threonine kinases. p70S6 kinase is predominantly localized in the cytoplasm and is essential in growth factors regulated cell proliferation, pathways involving cell motility, such as metastases, the immune response and tissue repair. p70S6 kinase acts downstream of phosphoinositide (PI) 3-kinase and its main physiological target is the S6 ribosomal protein, which is involved in upregulation of protein synthesis. The kinase activity of p70S6 kinase leads to an increase in protein synthesis and cell proliferation. Amplification of the region of DNA encoding p70S6 kinase and overexpression are seen in some breast cancer cell lines.

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