AVANTI POLAR LIPIDS , CYGNUS , LARODAN , ADIPOGEN , MYBIOSOURCE , SERVA NORDMARK, BIOWORLD, EDGEBIO , PANREAC APPLICHEM
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Product description: Monoclonal Antibody. Recognizes human and mouse periostin. Detects the FAS1-2 domain of periostin at a new binding site for the integrins alphavbeta3 and alphavbeta5. Isotype: Mouse IgMkappa. Clone: OC-20. Applications: FUNC (Blocking), ICC. Liquid. In 20mM sodium phosphate buffer, pH7.6 containing 150mM sodium chloride. Periostin is a 90-kDa matricellular protein that consists of a typical signal sequence, followed by a cysteine-rich region, an EMI domain (protein-protein interactions), four tandem fasciclin-like domains that are responsible for integrin binding, and a C-terminal region. Periostin was originally isolated as an osteoblast-specific factor that functions as a cell adhesion molecule for pre-osteoblasts and in osteoblast recruitment, attachment and spreading. Periostin is also involved in many fundamental biological processes such as cell proliferation, cell invasion and angiogenesis. Periostin expression is increased by both transforming growth factor beta1 (TGF-beta1) and bone morphogenetic protein 2 (BMP-2). Changes in periostin expression are commonly detected in various cancers and pre-cancerous conditions, and periostin may be involved in regulating cancer cell activities that contribute to tumorigenesis, cancer progression and metastasis. Periostin has shown to be involved in many aspects of allergic inflammation, such as eosinophil recruitment, airway remodeling, development of a Th2 phenotype and increased expression of inflammatory mediators. It is evaluated as a biomarker for bronchial asthma and airway inflammation.
Alternate Names/Synonyms: Osteoblast-specific Factor 2; OSF-2; Postn
Product Type: Monoclonal Antibody
Isotype: Mouse IgMkappa
Immunogen: Recombinant fragments of human periostin.
Applications: FUNC (Blocking), ICC
Species Crossreactivity: Human, Mouse
Specificity: Recognizes human and mouse periostin. Detects the FAS1-2 domain of periostin at a new binding site for the integrins alphavbeta3 and alphavbeta5.
Purity: >95% (SDS-PAGE)
Concentration: Lot dependent
Formulation: Liquid. In 20mM sodium phosphate buffer, pH7.6 containing 150mM sodium chloride.
Short Term Storage: +4°C
Long Term Storage: -20°C
Shipping: BLUE ICE
Use & Stability: Stable for at least 1 year after receipt when stored at -20°C.
Literature References: Identification of a novel cell binding site of periostin involved in tumour growth: P. Orecchia, et al.; Eur. J. Cancer 47, 2221 (2011) | Periostin promotes fibrosis and predicts progression in patients with idiopathic pulmonary fibrosis: P.K. Naik, et al.; Am. J. Physiol. Lung Cell Mol. Physiol. 303, L1046 (2012) | Periostin is required for maximal airways inflammation and hyperresponsiveness in mice: J.K. Bentley, et al.; J. Allergy Clin. Immunol. 134, 1433 (2014) | Periostin is a novel therapeutic target that predicts and regulates glioma malignancy: A.M. Mikheev, et al.; Neuro Oncol. 17, 372 (2015) | Periostin: its role in asthma and its potential as a diagnostic or therapeutic target: W. Li, et al.; Resp. Res. 16, 57 (2015) | Imaging of secreted extracellular periostin, an important marker of invasion in the tumor microenvironment in esophageal cancer: P. Heidari, et al.; J. Nucl. Med. 56, 1246 (2015)
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