AVANTI POLAR LIPIDS , CYGNUS , LARODAN , ADIPOGEN , MYBIOSOURCE , SERVA NORDMARK, BIOWORLD, EDGEBIO , PANREAC APPLICHEM
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Product description: Monoclonal Antibody. Recognizes human and mouse periostin. Isotype: Mouse IgG1kappa. Clone: Stiny-1. Applications: ELISA, IHC, WB. Liquid. In PBS containing 0.02% sodium azide. Periostin is a 90-kDa matricellular protein that consists of a typical signal sequence, followed by a cysteine-rich region, an EMI domain (protein-protein interactions), four tandem fasciclin-like domains that are responsible for integrin binding, and a C-terminal region. Periostin was originally isolated as an osteoblast-specific factor that functions as a cell adhesion molecule for pre-osteoblasts and in osteoblast recruitment, attachment and spreading. Periostin is also involved in many fundamental biological processes such as cell proliferation, cell invasion and angiogenesis. Periostin expression is increased by both transforming growth factor beta1 (TGF-beta1) and bone morphogenetic protein 2 (BMP-2). Changes in periostin expression are commonly detected in various cancers and pre-cancerous conditions, and periostin may be involved in regulating cancer cell activities that contribute to tumorigenesis, cancer progression and metastasis. Periostin has shown to be involved in many aspects of allergic inflammation, such as eosinophil recruitment, airway remodeling, development of a Th2 phenotype and increased expression of inflammatory mediators. It is evaluated as a biomarker for bronchial asthma and airway inflammation.
Alternate Names/Synonyms: Osteoblast-specific Factor 2; OSF-2; Postn
Product Type: Monoclonal Antibody
Isotype: Mouse IgG1kappa
Immunogen: Full-length human periostin.
Labels - Conjugates: Biotin
Applications: ELISA, IHC, WB
Species Crossreactivity: Human, Mouse
Specificity: Recognizes human and mouse periostin.
Purity: >95% (SDS-PAGE)
Formulation: Liquid. In PBS containing 0.02% sodium azide.
Short Term Storage: +4°C
Long Term Storage: -20°C
Shipping: BLUE ICE
Use & Stability: Stable for at least 1 year after receipt when stored at -20°C.
Literature References: Interactions between cancer stem cells and their niche govern metastatic colonization: I. Malanchi, et al.; Nature 481, 85 (2012) | Periostin contributes to the acquisition of multipotent stem cell-like properties in human mammary epithelial cells and breast cancer cells: X. Wang, et al.; PLoS One 8, e72962 (2013) | The perivascular niche regulates breast tumour dormancy: C.M. Ghajar, et al.; Nat. Cell Biol. 15, 807-817 (2013)
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