anti-Rab6-GTP, mAb (rec.) (AA2)

Product description: Recombinant Antibody. Recognizes human, mouse and Drosophila GTP-bound Rab6a and Rab6b and mutant Rab6Q72L. Does not detect Rab6•GDP. Species cross-reactivity: Drosophila, Human, Mouse. Clone: AA2. Isotype: Human IgG2lambda. Applications: ICC. Host: Purified from HEK 293 cell culture supernatant. Liquid. In PBS containing 10% glycerol and 0.02% sodium azide. Rab6 is involved in protein transport. It is a regulator of membrane traffic from the Golgi apparatus towards the endoplasmic reticulum (ER).

Alternate Names/Synonyms: Ras-related Protein Rab-6

Product Type: Recombinant Antibody

Clone: AA2

Isotype: Human IgG2lambda

Immunogen: Recombinant Rab6AQ72L, a GTP-locked mutant of Rab6A in which Gln72 is replaced by Leu.

Applications: ICC

Species Crossreactivity: Drosophila, Human, Mouse

Specificity: Recognizes human, mouse and Drosophila GTP-bound Rab6a and Rab6b and mutant Rab6Q72L. Does not detect Rab6•GDP.

Purity: >95% (SDS-PAGE)

Concentration: 1mg/ml

Formulation: Liquid. In PBS containing 10% glycerol and 0.02% sodium azide.

Short Term Storage: +4°C

Long Term Storage: -20°C

Shipping: BLUE ICE

Use & Stability: Stable for at least 1 month after receipt when stored at +4°C. Stable for at least 1 year after receipt when stored at -20°C.

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Literature References: Recombinant antibodies to the small GTPase Rab6 as conformation sensors: C. Nizak, et al.; Science 300, 984 (2003) | Rab6A and Rab6A' GTPases play non-overlapping roles in membrane trafficking: E. Del Nery, et al.; Traffic 7, 394 (2006) | Characterization of single chain antibody targets through yeast two hybrid: O. Vielemeyer, et al; BMC Biotechnol. 10, 59 (2010)