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Product description: Polyclonal Antibody. Recognizes endogenous ST2 by Flow Cytometry. Source: Rabbit. Applications: ELISA, FACS, WB. Liquid. In PBS containing 0.02% sodium azide. ST2 is a member of the Toll/IL-1 receptor family. Two forms of the protein exist, a soluble form known as ST2 and a membrane anchored form known as ST2L. The membrane form is expressed by Th2 cells and bone marrow derived mast cells, whereas the soluble form is expressed by serum-stimulated fibroblasts. It binds IL-33 and is structurally similar to IL-1R1. Type 2 innate lymphoid cells (ILC2), originally referred to as natural helper (NH) cells, are a novel target of IL-33. Lung ILC2s participate in the induction of airway inflammation in influenza virus-infected mice and papain-administrated mice. Soluble ST2 plays a role in protecting ILC2 from IL-33 stimulation and thereby maintaining them in a naïve state and might be important for the regulation of several disease. Blocking with anti-ST2 antibodies has been shown to alleviate experimental arthritis and airway inflammation. The IL-33-ST2 axis is is involved across a range of diseases including asthma, allergies, obesity and cardiac disease.
Alternate Names/Synonyms: Interleukin-1 Receptor-like 1; IL-1 Receptor-like 1; IL1RL1; IL-33 Receptor; Interleukin-33 Receptor
Product Type: Polyclonal Antibody
Immunogen: Recombinant human soluble ST2.
Labels - Conjugates: ATTO 647N
Applications: ELISA, FACS, WB
Species Crossreactivity: Human
Specificity: Recognizes endogenous ST2 by Flow Cytometry.
Formulation: Liquid. In PBS containing 0.02% sodium azide.
Short Term Storage: +4°C
Long Term Storage: +4°C
Shipping: BLUE ICE
Use & Stability: Keep conjugated formats at +4°C. Stable for at least 1 year after receipt when stored at +4°C.
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