anti-TIA1 (human), Rabbit Monoclonal (RM490)

Product description: Recombinant Antibody. This antibody reacts to human TIA-1. Source: Rabbit. Isotype: Rabbit IgG. Immunogen: A peptide corresponding to the C-terminus of human TIA1. Applications: WB. TIA1, also named as p40-TIA-1, is involved in alternative pre-RNA splicing and regulation of mRNA translation by binding to AU-rich elements (AREs) located in mRNA 3' untranslated regions (3' UTRs). It possesses nucleolytic activity against cytotoxic lymphocyte target cells. TIA1 may be involved in apoptosis. Similar to the ALS-related disease proteins TDP-43, hnRNPA1, and FUS, TIA1 is an RNA-binding protein containing a prionlike LCD and assembles into membrane-less organelles, including SGs. TIA1 mutations significantly increased the propensity of TIA1 protein to undergo phase transition. In live cells,TIA1 mutations delayed stress granule (SG) disassembly and promoted the accumulation of non-dynamic SGs that harbored TDP-43.

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