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100 mg

Ref. SYN-1011-M100
SynKinase
896466-04-9

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Détails Produit

Product description: Chemical. CAS: 896466-04-9. Formula: C19H23N7O2. MW: 381.4. Aurora kinases play a key role in the regulation of mitosis and in recent years have become attractive targets for the treatment of cancer. AT9283 is a powerful inhibitor of Aurora A and B kinases as well as several other important kinases including JAK2 and Abl (T315I). AT9283 has also been shown effective in mouise xenograft models and has been studied as a possible clinical candidate. Effective IC(50) doses for Aurora kinases are in the low 2-3nM range, and inhibition of a number of other kinases including JAK2 has been reported at 1-10nM.

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