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5 mg

Ref. SYN-1214-M005
SynKinase
1204144-28-4

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Neuf 96.00 H.T.

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Détails Produit

Product description: Potent, highly selective and orally available Pim kinase inhibitor that effectively inhibits all three isoforms Pim-1, Pim-2 and Pim-3 at <5nM or <150 nM in enzyme and cell assays, respectively. Potently inhibits colony growth and Pim signalling substrates in primary AML cells from bone marrow that are Flt3 wild-type or Flt3 internal tandem duplication mutants. Upregulation of Pim kinases is observed in several types of leukemias and lymphomas. Pim-1, -2 and -3 promote cell proliferation and survival downstream of cytokine and growth factor signaling pathways.

Alternate Names/Synonyms: AZD-1208

Product Type: Chemical

Molecular Formula: C21H21N3O2S

Molecular Weight: 379.5

CAS: 1204144-28-4

Purity: >95%

InChiKey: MCUJKPPARUPFJM-UWCCDQBKSA-N

Appearance Solid.

Solubility: Soluble in DMSO.

Short Term Storage: +4°C

Long Term Storage: -20°C

Shipping: AMBIENT

Use & Stability: Stable for at least 2 years after receipt when stored at -20°C.

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