B7-H5 [VISTA] (human) (rec.) (His)

Product Description: Platelet receptor Gi24 (also known as Dies1, SISP1 and C10orf54) is a 55-65 kDa member of the Ig superfamily. It is a transmembrane molecule expressed in bone, on embryonic stem cells (ESCs), and on tumor cell surfaces. On ESCs, Gi24 appears to positively interact with BMP-4, potentiating BMP signaling and the transition from an undifferentiated to a differentiated state. On tumor cells, Gi24 both promotes MT1-MMP expression and activity and serves as a substrate for MT1-MMP. This increases the potential for cell motility. Human Gi24 undergoes proteolytic cleavage by MT1-MMP, generating a soluble 30 kDa extracellular fragment plus a 25-30 kDa membrane-bound fragment.

Alternate Names/Synonyms: Platelet Receptor Gi24; Dies1; Differentiation of ESC-1; SISP1; C10orf54; VISTA

Product type: Protein

Source / Host: HEK 293 cells

Sequence: The extracellular domain of human B7-H5 (aa 33-194) is fused at the C-terminus to a His-tag.

Species Crossreactivity: Human

Molecular Weight: ~32kDa (SDS-PAGE)

TAGs: His

Purity: >95% (SDS-PAGE)

Endotoxin: <0.01EU/µg protein (LAL test; Lonza).

Formulation: Lyophilized from 0.2µm-filtered solution in PBS.

Handling Advice: Avoid freeze/thaw cycles. PBS containing at least 0.1% BSA should be used for further dilutions.

Short Term Storage: +4°C

Long Term Storage: -20°C

Shipping: BLUE ICE

Use & Stability: Stable for at least 1 year after receipt when stored at -20°C. Working aliquots are stable for up to 3 months when stored at -20°C.

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