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100 µg

Ref. CHI-HF-211B7H6-C100
CHIMERIGEN

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Neuf 350.00 H.T.

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Détails Produit

Product Description: B7-H6 is a glycosylated member of the B7 family of immune costimulatory proteins. Orthologs in mouse and rat have not been identified. The Ig-like V domain mediates 1:1 stoichiometric binding of B7-H6 to NKp30 expressed on NK cells. It does not show binding to NKp44, NKp46, or NKG2D. Ligation of NKp30 by B7-H6 induces NK cell activation and target cell cytolysis. B7-H6 is expressed on a wide range of hematopoietic, carcinoma, and melanoma tumor cells, which is consistent with the detection of NKp30 binding sites on many tumors. The expression of NKp30 ligands on tumor cells correlates with tumor cell sensitivity to NKp30-dependent cell lysis.

Product type: Protein

Source / Host: HEK 293 cells

Sequence: The extracellular domain of human B7-H6 (aa 25-262) is fused to the N-terminus of the Fc region of mouse IgG2a.

Species Crossreactivity: Human

Molecular Weight: ~80kDa (SDS-PAGE)

TAGs: Fc

Purity: >98% (SDS-PAGE)

Endotoxin: <5EU/mg protein (LAL test; Lonza).

Formulation: Lyophilized from 0.2µm-filtered solution in PBS.

Handling Advice: Avoid freeze/thaw cycles.

Short Term Storage: +4°C

Long Term Storage: -20°C

Shipping: BLUE ICE

Use & Stability: Stable for at least 1 year after receipt when stored at -20°C. Working aliquots are stable for up to 3 months when stored at -20°C.

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