Tel. : 01 45 33 67 17 / E-mail : coger@coger.fr
AVANTI POLAR LIPIDS , CYGNUS , LARODAN , ADIPOGEN , MYBIOSOURCE , SERVA NORDMARK, BIOWORLD, EDGEBIO , PANREAC APPLICHEM
Ajouter au panier
Le produit a été ajouté au panier Le stock est insuffisant. unités ont été rajoutées au panier Total:
|
Stock épuisé.
En rupture de stock
|
Quantité minimum d'achat
La quantité minimum d'achat n'est pas atteinte
|
photos non contractuelles
Product description: CC-401 is a competitive inhibitor of the ATP binding site in the active, phosphorylated, form of JNK. This prevents JNK from phosphorylating its various target molecules, including the amino terminus of c-Jun. It is a potent inhibitor of all three forms of JNK (Ki of 25-50 nM), and has at least 40-fold selectivity for JNK compared with other related kinases, including: p38, ERK, IKK2, PKC, Lck, and ZAP70. CC-401 acts to inhibit JNK signaling by competitive binding to the adenosine triphosphate-binding site in the active, phosphorylated, form of JNK, resulting in inhibition of the phosphorylation of JNK targets, such as the amino-terminal activation domain of the transcription factor, c-Jun. In cell-based assays, 1-5 muM CC-401 provides specific JNK inhibition.
Alternate Names/Synonyms: CC401
Product Type: Chemical
Molecular Formula: C22H24N6O . HCl
Molecular Weight: 388.4 . 36.5
CAS: 1438391-30-0
Purity: >95%
InChiKey: OIBVXKYKWOUGAO-UHFFFAOYSA-N
Appearance Solid.
Solubility: Soluble in DMSO.
Short Term Storage: +4°C
Long Term Storage: -20°C
Shipping: AMBIENT
Use & Stability: Stable for at least 2 years after receipt when stored at -20°C.
Alerte
Veuillez saisir les champs obligatoires! |