AVANTI POLAR LIPIDS , CYGNUS , LARODAN , ADIPOGEN , MYBIOSOURCE , SERVA NORDMARK, BIOWORLD, EDGEBIO , PANREAC APPLICHEM
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Product Description: Macrophage Inflammatory Protein-3 (MIP3A) or Chemokine (C-C motif) ligand 20 (CCL20) or liver activation regulated chemokine (LARC) or is a small cytokine belonging to the CC chemokine family that attracts immature dendritic cells and memory T lymphocytes, both expressing CCR6. Depending on the cell type, this chemokine was found to be inducible by cytokines (IL-1beta) and by bacterial, viral, or plant products. MIP3A / CCL20 is Expressed predominantly in the liver, lymph nodes, appendix, peripheral blood lymphocytes, and fetal lung. Low levels of MIP3A / CCL20 has been seen in thymus, prostate, testis, small intestine and colon. As a chemotactic factor, MIP3A / CCL20 attracts lymphocytes and, slightly, neutrophils, but not monocytes. This chemokine may Inhibit proliferation of myeloid progenitors in colony formation assays and it may be involved in formation and function of the mucosal lymphoid tissues by attracting lymphocytes and dendritic cells towards epithelial cells. Its C-terminal processed forms have been shown to be equally chemotactically active for leukocytes. Deregulation of miRNAs and chemokine CCL20 was shown to play a role in colorectal cancer (CRC) pathogenesis and the regulation of CCL20 expression by miR-21 might be a regulatory mechanism involved in progression of colorectal cancer (CRC).
Alternate Names/Synonyms: Chemokine (C-C motif) ligand 20; LARC; MIP-3A; ST38; Scya20; Exodus-1
Product type: Protein
Source / Host: HEK 293 cells
Sequence: The extracellular domain of human CCL20 (aa 27-96) is fused to the N-terminus of the Fc region of human IgG1.
Species Crossreactivity: Human
Molecular Weight: ~38kDa (SDS-PAGE)
Purity: >95% (SDS-PAGE)
Endotoxin: <5EU/mg protein (LAL test; Lonza).
Formulation: Lyophilized from 0.2µm-filtered solution in PBS.
Handling Advice: Avoid freeze/thaw cycles.
Short Term Storage: +4°C
Long Term Storage: -20°C
Shipping: BLUE ICE
Use & Stability: Stable for at least 1 year after receipt when stored at -20°C. Working aliquots are stable for up to 3 months when stored at -20°C.
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