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100 µg

Ref. CHI-HF-211CD134-C100
CHIMERIGEN

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Neuf 350.00 H.T.
en stock

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Détails Produit

Product Description: CD134 (OX40) is a T cell activation antigen structurally belonging to a lymphocyte-specific subgroup of the nerve growth factor and tumor necrosis factor receptor superfamily, which also includes the T cell antigen CD27, B cell antigen CD40, FAS antigen and the T cell activation antigen 4-1BB. The human CD134 protein is expressed only on activated CD4+ T blasts, and its ligand has been identified as gp34. Interactions between CD134 and its ligand in vivo are necessary for the differentiation of activated B cells into highly immunoglobulin-producing cells, however not involved in other pathways of antigen-driven differentiation of B cells such as development of memory cells in the germinal centers. In addition, the CD134 and gp34 system directly mediate adhesion of activated T cells to vascular endothelial cells, and contribute to growth stimulation of the virus-infected T cells.

Alternate Names/Synonyms: OX40; Tumor Necrosis Factor Receptor Superfamily Member 4; TNFRSF4; ACT35; TXGP1L

Product type: Protein

Source / Host: HEK 293 cells

Sequence: The extracellular domain of human CD134 (aa 29-216) is fused to the N-terminus of the Fc region of mouse IgG2a.

Species Crossreactivity: Human

Biological Activity: Measured by its binding ability in a functional ELISA.

Molecular Weight: ~65kDa (SDS-PAGE)

TAGs: Fc

Purity: >98% (SDS-PAGE)

Endotoxin: <5EU/mg protein (LAL test; Lonza).

Formulation: Lyophilized from 0.2µm-filtered solution in PBS.

Handling Advice: Avoid freeze/thaw cycles.

Short Term Storage: +4°C

Long Term Storage: -20°C

Shipping: BLUE ICE

Use & Stability: Stable for at least 1 year after receipt when stored at -20°C. Working aliquots are stable for up to 3 months when stored at -20°C.

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