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100 µg

Ref. CHI-HF-211CD137-C100
CHIMERIGEN

photos non contractuelles

Neuf 350.00 H.T.
en stock

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Détails Produit

Product Description: Human CD137 (4-1BB) is a costimulatory molecule of the tumor necrosis factor (TNF) receptor superfamily. The glycoprotein 4-1BB is expressed mainly on activated CD4+ and CD8+ T cells and binds to a high-affinity ligand (4-1BBL) expressed on several antigen-presenting cells such as macrophages and activated B cells. Upon ligand binding, 4-1BB is associated with the tumor receptor-associated factors (TRAF), the adaptor protein and mediates downstream signaling events including the activation of NF-kappaB and cytokine production. 4-1BB signaling either by binding to 4-1BBL or by antibody ligation delivers signals for T cell activation and growth as well as monocyte proliferation and B cell survival, and plays a important role in the amplification of T cell-mediated immune responses. In contrast, it can also enhance activation-induced T cell apoptosis when triggered by engagement of the TCR/CD3 complex. In addition, the 4-1BB/4-1BBL costimulatory pathway has been shown to augment secondary CTL responses to several viruses and increase antitumor immunity. 4-1BB is therefore a promising candidate for immunotherapy of human cancer.

Alternate Names/Synonyms: Tumor Necrosis Factor Receptor Superfamily Member 9; TNFRSF9; 4-1BB; 4-1BB Ligand Receptor T Cell; Antigen 4-1BB Homolog; T Cell Antigen ILA; CD137 Antigen; CDw137; ILA; MGC2172

Product type: Protein

Source / Host: HEK 293 cells

Sequence: The extracellular domain of human CD137 [4-1BB] (aa 19-184) is fused to the N-terminus of the Fc region of mouse IgG2a.

Species Crossreactivity: Mouse

Biological Activity: Measured by its binding ability in a functional ELISA.

Molecular Weight: ~55kDa (SDS-PAGE)

TAGs: Fc

Purity: >98% (SDS-PAGE)

Endotoxin: <5EU/mg protein (LAL test; Lonza).

Formulation: Lyophilized from 0.2µm-filtered solution in PBS.

Handling Advice: Avoid freeze/thaw cycles.

Short Term Storage: +4°C

Long Term Storage: -20°C

Shipping: BLUE ICE

Use & Stability: Stable for at least 1 year after receipt when stored at -20°C. Working aliquots are stable for up to 3 months when stored at -20°C.

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