CD24 (human)-muIg Fusion Protein (preservative free)

Product description: Recombinant Protein. The extracellular domain (33aa) of human CD24 is fused to the murine IgG2a Fc (233 aa). Source: W2. 50 mM Sodium Phosphate pH 7.5, 100mM KCl, 150mM NaCl. CD24 is a highly glycosylated protein expressed as glycosyl-phosphatidyl-inositol (GPI) anchored molecule. It is widely expressed, mainly on T cells, B cells and is upregulated in numerous types of cancers. It has costimulatory activity for antigen specific T cell responses. Polymorphisms of human CD24 are associated with several autoimmune diseases. Recently, a new role as negative regulator of the immune response has been reported. CD24-deficient mice are more sensitive to inflammatory responses. CD24 together with the membrane protein SIGLEC interacts with danger-associated molecular patterns (DAMPs), such as HMGB1, HSP90 or HSP70. CD24/SIGLEC complex may differentially regulate the host response to DAMPs and PAMPs (pathogen-associated molecular patterns).

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