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AVANTI POLAR LIPIDS , CYGNUS , LARODAN , ADIPOGEN , MYBIOSOURCE , SERVA NORDMARK, BIOWORLD, EDGEBIO , PANREAC APPLICHEM
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Colistin sulfate (Ph. Eur. Grade)
1 g
photos non contractuelles
Détails Produit
Product description: Chemical. CAS: 1264-72-8. Formula: 2(C52H98N16O13) . 5(H2SO4) (unspec.). MW: 2801.7. Isolated from Bacillus polymyxa. Very potent polymyxin antibiotic. Has only one amino acid difference compared to polymyxin B. Antimicrobial. Targets the lipopolysaccharide (LPS) of the outer membrane of Gram-negative bacteria. Competitively displaces divalent cations (Ca2+ and Mg2+) from the negatively-charged phosphate groups LPS, causing disruption of the membrane. This increases the permeability of the cell envelope, leakage of cell contents, leading to apoptosis and cell death. Used against multidrug-resistant Gram-negative bacterial infections.
Alternate Names/Synonyms: Polymyxin E; Belcomycin; Colimycin
Product Type: Chemical
Molecular Formula: 2(C52H98N16O13) . 5(H2SO4) (unspec.)
Molecular Weight: 2801.7
CAS: 1264-72-8
Source / Host: Isolated from Bacillus polymyxa.
Purity: >77% (Mixture, primarly colistin A and B).
InChiKey: YKQOSKADJPQZHB-QNPLFGSASA-N
Appearance: White to off-white powder.
Solubility: Soluble in water.
Short Term Storage: +4°C
Long Term Storage: +4°C
Long Shipping: AMBIENT
Use & Stability: Stable for at least 2 years after receipt when stored at +4°C.
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