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5 g

Ref. AG-CN2-0512-G005

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Neuf 320.00 H.T.


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Détails Produit

Product description: Chemical. CAS: 1264-72-8. Formula: 2(C52H98N16O13) . 5(H2SO4) (unspec.). MW: 2801.7. Isolated from Bacillus polymyxa. Very potent polymyxin antibiotic. Has only one amino acid difference compared to polymyxin B. Antimicrobial. Targets the lipopolysaccharide (LPS) of the outer membrane of Gram-negative bacteria. Competitively displaces divalent cations (Ca2+ and Mg2+) from the negatively-charged phosphate groups LPS, causing disruption of the membrane. This increases the permeability of the cell envelope, leakage of cell contents, leading to apoptosis and cell death. Used against multidrug-resistant Gram-negative bacterial infections.

Alternate Names/Synonyms: Polymyxin E; Belcomycin; Colimycin

Product Type: Chemical

Molecular Formula: 2(C52H98N16O13) . 5(H2SO4) (unspec.)

Molecular Weight: 2801.7

CAS: 1264-72-8

Source / Host: Isolated from Bacillus polymyxa.

Purity: >77% (Mixture, primarly colistin A and B).


Appearance: White to off-white powder.

Solubility: Soluble in water.

Short Term Storage: +4°C

Long Term Storage: +4°C

Long Shipping: AMBIENT

Use & Stability: Stable for at least 2 years after receipt when stored at +4°C.

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