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AVANTI POLAR LIPIDS , CYGNUS , LARODAN , ADIPOGEN , MYBIOSOURCE , SERVA NORDMARK, BIOWORLD, EDGEBIO , PANREAC APPLICHEM
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Product description: Chemical. CAS: 2733581-46-7. Formula: C21H28O5. MW: 360.45. Collinolactone has neuroprotective and anti-neurodegenerative effects by reducing intracellular oxidative stress. It protects against glutamate-induced oxidative stress in a dose-dependent manner. Collinolactone is a potential anti-Alzheimer agent with A?-disaggregating activity. It showed dissociative effect on A? aggregates and tau tangles in vitro, with significantly reduced apoptosis and inflammation in neuronal and glial cells. In vivo studies on APP/PS1 double transgenic mice showed substantially dissociated hippocampal plaques. A set of semisynthetic collinolactone analogs (but not collinolactone) has shown inhibitory effects on a L929 cell line.
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