Dermcidin-1L (human) . TFA

Product description: Chemical. CAS: 478898-18-9. Formula: C210H359N57O71 . C2HF3O2. MW: 4818.5 . 114.0. Dermcidin is an antimicrobial peptide constitutively expressed in sweat glands, secreted into the sweat and transported to the epidermal surface. In sweat it is proteolytically processed to Dermcidin-1L (DCD-1L) that has antimicrobial activity against a variety of pathogenic microorganisms and other peptides (e.g. DCD-1, Y-P30). Dermcidin-1L (DCD-1L) is a 48-amino acid antimicrobial peptide (AMP) with a Leu residue on the C-terminus, secreted in sweat and part of the innate host defense of the immune system. Unlike most AMPs, which are cationic, DCD-1L has a net negative charge. DCD-1L displays antimicrobial activity thereby limiting skin infection by potential pathogens in the first few hours after bacterial colonization. Highly effective against E.coli, E.faecalis, S.aureus and C.albicans. DCD-1L is first monomeric in human sweat. DCD-1L interaction with negatively charged bacterial membrane phospholipids leads to Zn(2+) dependent formation of oligomeric DCD-1L complexes in the bacterial membrane, which subsequently leads to ion channel formation resulting in membrane depolarization and bacterial cell death. The gene products of DCD have been reported to be a neuronal survival factor, a putative oncogene in breast cancer and a proteolysis-inducing factor (PIF) that induces skeletal muscle proteolysis to cause cancer cachexia.

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