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Product description: Erlotinib inhibits EGFR tyrosine kinase auto-phosphorylation. Studies in cell lines and enzyme assays have shown that erlotinib inhibits EGFR at concentrations significantly lower than those needed to inhibit c-src and v-abl. It has an IC(50) of 2nM against EGFR. It is >1000-fold more sensitive for EGFR than for c-Src or v-Abl.
Alternate Names/Synonyms: OSI774; CP-358774; Tarceva; NSC718781
Product Type: Chemical
Molecular Formula: C22H23N3O4 . HCl
Molecular Weight: 393.4 . 36.5
CAS: 183319-69-9
Purity: >95%
InChiKey: GTTBEUCJPZQMDZ-UHFFFAOYSA-N
Appearance Solid.
Solubility: Soluble in DMSO. Slightly soluble (<1mg/ml) in ethanol.
Short Term Storage: +4°C
Long Term Storage: -20°C
Shipping: AMBIENT
Use & Stability: Stable for at least 2 years after receipt when stored at -20°C.
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