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AVANTI POLAR LIPIDS , CYGNUS , LARODAN , ADIPOGEN , MYBIOSOURCE , SERVA NORDMARK, BIOWORLD, EDGEBIO , PANREAC APPLICHEM
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Product description: Chemical. CAS: 883726-13-4 [GE81112A], 883726-14-5 [GE81112B]. Formula: C24H34ClN9O10 [A], C24H35ClN10O10 [B]. MW: 644.0 [A]659.1 [B]. Isolated from Strepomyces sp. Tetrapeptide antibiotic. Potent and selective inhibitor of bacterial protein synthesis. Translational inhibitor specific for the initiation phase. Binds to the 30S ribosomal subunit and specifically inhibits P-site decoding of the mRNA initiation codon by the fMet-tRNA anticodon. Inhibits in vivo protein synthesis but not other cell functions such as DNA duplication, transcription and cell wall synthesis. Antibacterial activity against some Gram-positive and Gram-negative bacteria. Unique scaffold for designing new drugs.
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