GITRL, Soluble (human) (rec.) (His)

Product Description: GITRL (Glucocorticoid-induced TNF receptor ligand) is expressed on dendritic cells (DC), monocytes, macrophages, B cells, activated T cells, endothelial cells, osteoclasts and various healthy non-lymphoid tissues (e.g. testis). GITRL is constitutively expressed and released as soluble form by solid tumors and various hematopoietic malignancies. GITRL causes differentiation of osteoclasts, activation of macrophages, but also alteration of carcinoma and leukemia cells and influences apoptosis. Binding to GITR is important in regulating T cell proliferation and TCR-mediated apoptosis. GITRL is implicated in development of autoimmune diseases and in the immune response against infectious pathogens and tumors.

Alternate Names/Synonyms: Glucocorticoid-induced TNF Receptor Ligand; AITRL; Activation-inducible TNF-related Ligand; TNFSF18

Product type: Protein

Source / Host: HEK 293 cells

Sequence: The extracellular domain of human GITRL (aa 74-199) is fused at the C-terminus to a His-tag.

Species Crossreactivity: Human

Molecular Weight: ~17kDa (SDS-PAGE)

TAGs: His

Purity: >90% (SDS-PAGE)

Endotoxin: <0.06EU/µg purified protein (LAL test; Lonza).

Formulation: Lyophilized from 0.2µm-filtered solution in PBS.

Handling Advice: After reconstitution, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles. PBS containing at least 0.1% BSA should be used for further dilutions.

Short Term Storage: +4°C

Long Term Storage: -20°C

Shipping: BLUE ICE

Use & Stability: Stable for at least 6 months after receipt when stored at -20°C. Working aliquots are stable for up to 3 months when stored at -20°C.

Lien vers la Fiche Technique