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5 mg

Ref. SYN-1158-M005
SynKinase
1206161-97-8

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Neuf 383.00 H.T.

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Détails Produit

Product description: GLPG0634 is a novel and specific inhibitor of JAK1 and JAK2 with IC(50) of 10nM and 28nM respectively measured by in vitro kinase assays (ATP 2µM). In particular GLPG0634, while being a potent inhibitor of JAK1 and JAK2 does not inhibit TYK2 or JAK3, and GLPG0634 exhibits a dramatically improved in vivo potency over structurally similar compounds. May be used for the prevention of variety of conditions in animals including inflammatory conditions, autoimmune diseases, proliferative diseases, transplant rejection, diseases involving impairment of cartilage turnover, congenital cartilage malformation and/or diseases associated with hypersecretion of IL-6.

Alternate Names/Synonyms: GLPG-0634; Filgotinib

Product Type: Chemical

Molecular Formula: C21H23N5O3S

Molecular Weight: 425.5

CAS: 1206161-97-8

Purity: >95%

InChiKey: RIJLVEAXPNLDTC-UHFFFAOYSA-N

Appearance Solid.

Solubility: Soluble in DMSO.

Short Term Storage: +4°C

Long Term Storage: -20°C

Shipping: AMBIENT

Use & Stability: Stable for at least 2 years after receipt when stored at -20°C.

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