Glucuronolactone

Product description: Chemical. CAS: 32449-92-6. Formula: C6H8O6. MW: 176.12. Synthetic. Naturally occurring carbohydrate derivative that is an important structural component of nearly all connective tissues and is also found in many plant gums. Metabolized to glucaric acid, xylitol, and L-xylulose, and humans may also be able to use glucuronolactone as a precursor for ascorbic acid synthesis. Used as a detoxicant. The liver uses glucose to create glucuronolactone, which inhibits the enzyme B-glucuronidase (metabolizes glucuronides), which should cause blood-glucuronide levels to rise. Glucuronides combine with toxic substances, such as morphine and depot medroxyprogesterone acetate, by converting them to water-soluble glucuronide-conjugates which are excreted in the urine. Used as building block and starting reagent for synthesis of drugs, optically active glucopyranoses and long-chain alkyl glucofuranosides.

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