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10 mg

Ref. SYN-1215-M010
SynKinase
579515-63-2

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Neuf 383.00 H.T.

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Détails Produit

Product description: Potent protein kinase VEGFR2 inhibitor (2nm range). Binds to the pseudokinase domain of MLKL and blocks cell death by necroptosis, as well. With regards to its role in necroptosis, it is an ATP-mimetic that was shown to bind recombinant mouse MLKL pseudokinase domain, which showed inhibited TSQ-induced death of mouse dermal fibroblasts by delaying MLKL translocation to the membrane. Appears therefore to be a valuable reagent to inhibit necroptosis. It also provides an important proof-of-principle that targeting catalytically-dead pseudoenzymes represents a feasible, emerging therapeutic avenue.

Alternate Names/Synonyms: AC1NS7PT; AGN-PC-0LQ49Y

Product Type: Chemical

Molecular Formula: C25H22F3N7O4S

Molecular Weight: 573.6

CAS: 579515-63-2

Purity: >95%

InChiKey: SNRUTMWCDZHKKM-UHFFFAOYSA-N

Appearance Solid.

Solubility: Soluble in DMSO.

Short Term Storage: +4°C

Long Term Storage: -20°C

Shipping: AMBIENT

Use & Stability: Stable for at least 2 years after receipt when stored at -20°C.

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