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AVANTI POLAR LIPIDS , CYGNUS , LARODAN , ADIPOGEN , MYBIOSOURCE , SERVA NORDMARK, BIOWORLD, EDGEBIO , PANREAC APPLICHEM
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Product description: Chemical. CAS: 1202388-64-4. Formula: C42H84INO5. MW: 810.02g/mol (iodide salt). Synthetic. CD14/TLR4 antagonist. Inhibitor of sterile inflammation. Synthetic TLR4/CD14 ligand with TLR4 modulating activities in vitro, and conferring protection against TLR4/CD14-mediated tissue damage and inflammation in vivo. Useful to explore CD14- dependent and TLR4-independent pathways and TLR4 activation by endogenous ligands (e.g. hyaluronic acid oligosaccharides, oxLDL, HMGB1) in sterile inflammation. Shown to inhibit neuropathic pain, secondary necrosis of acute drug-induced liver failure and vascular inflammation, and abdominal aortic aneurysm by blocking non-hematopoietic TLR4 signaling. Useful tool, where inhibition of sterile (auto-) inflammation is desired, without compromising TLR4s key role in the defense of pathogens.
Alternate Names/Synonyms: Methyl 6-deoxy-6-N-dimethyl-N-cyclopentylammonium-2,3-di-O-tetradecyl-alpha-D-glucopyranoside iodide
Product Type: Chemical
Molecular Formula: C42H84INO5
Molecular Weight: 810.02g/mol (iodide salt)
CAS: 1202388-64-4
Source / Host: Synthetic.
Purity: >98% (TLC)
InChiKey: InChI=1/C42H84NO5.HI/c1-6-8-10-12-14-16-18-20-22-24-26-30-34-46-40-39(44)38(36-43(3,4)37-32-28-29-33-37)48-42(45-5)41(40)47-35-31-27-25-23-21-19-17-15-13-11-9-7-2;/h37-42,44H,6-36H2,1-5H3;1H/q+1;/p-1/fC42H84NO5.I/h;1h/qm;-1
Appearance: White solid.
Solubility: Soluble in Methanol, DMSO and Ethanol 1:1 (vol:vol): >10mM.
Short Term Storage: +4°C
Long Term Storage: +4°C
Long Shipping: AMBIENT
Use & Stability: Stable for at least 1 year after receipt when stored at +4°C.
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