IAXO-102 (CD14/TLR4 Antagonist) (synthetic)

Product description: Chemical. CAS: 1115270-63-7. Formula: C35H71NO5. MW: 585.94g/mol. Synthetic. CD14/TLR4 antagonist. Inhibitor of sterile inflammation. Synthetic TLR4/CD14 ligand with TLR4 modulating activities in vitro, and conferring protection against TLR4/CD14-mediated tissue damage and inflammation in vivo. Useful to explore CD14- dependent and TLR4-independent pathways and TLR4 activation by endogenous ligands (e.g. hyaluronic acid oligosaccharides, oxLDL, HMGB1) in sterile inflammation. Shown to inhibit neuropathic pain, secondary necrosis of acute drug-induced liver failure and vascular inflammation, and abdominal aortic aneurysm by blocking non-hematopoietic TLR4 signaling. Useful tool, where inhibition of sterile (auto-) inflammation is desired, without compromising TLR4’s key role in the defense of pathogens.

Alternate Names/Synonyms: Methyl 6-deoxy-6-amino-2,3-di-O-tetradecyl-alpha-D-glucopyranoside

Product Type: Chemical

Molecular Formula: C35H71NO5

Molecular Weight: 585.94g/mol

CAS: 1115270-63-7

Source / Host: Synthetic.

Purity: >98% (TLC)

InChiKey: InChI=1/C35H71NO5/c1-4-6-8-10-12-14-16-18-20-22-24-26-28-39-33-32(37)31(30-36)41-35(38-3)34(33)40-29-27-25-23-21-19-17-15-13-11-9-7-5-2/h31-35,37H,4-30,36H2,1-3H3

Appearance: White solid.

Solubility: Soluble in Methanol, DMSO and Ethanol 1:1 (vol:vol): >10mM.

Short Term Storage: +4°C

Long Term Storage: +4°C

Long Shipping: AMBIENT

Use & Stability: Stable for at least 1 year after receipt when stored at +4°C.

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