IAXO-103 (CD14/TLR4 Antagonist) (synthetic)

Product description: Chemical. CAS: 1202208-36-3. Formula: C42H78INO2. MW: 755.98g/mol (iodide salt). Synthetic. CD14/TLR4 antagonist. Inhibitor of sterile inflammation. Synthetic TLR4/CD14 ligand with TLR4 modulating activities in vitro, and conferring protection against TLR4/CD14-mediated tissue damage and inflammation in vivo. Useful to explore CD14- dependent and TLR4-independent pathways and TLR4 activation by endogenous ligands (e.g. hyaluronic acid oligosaccharides, oxLDL, HMGB1) in sterile inflammation. Shown to inhibit neuropathic pain, secondary necrosis of acute drug-induced liver failure and vascular inflammation, and abdominal aortic aneurysm by blocking non-hematopoietic TLR4 signaling. Useful tool, where inhibition of sterile (auto-) inflammation is desired, without compromising TLR4’s key role in the defense of pathogens.

Alternate Names/Synonyms: N-(3,4-bis-Tetradecyloxy-benzyl)-N-cyclopentyl-N,N-dimethylammonium iodide

Product Type: Chemical

Molecular Formula: C42H78INO2

Molecular Weight: 755.98g/mol (iodide salt)

CAS: 1202208-36-3

Source / Host: Synthetic.

Purity: >98% (TLC)

InChiKey: InChI=1/C42H78NO2.HI/c1-5-7-9-11-13-15-17-19-21-23-25-29-35-44-41-34-33-39(38-43(3,4)40-31-27-28-32-40)37-42(41)45-36-30-26-24-22-20-18-16-14-12-10-8-6-2;/h33-34,37,40H,5-32,35-36,38H2,1-4H3;1H/q+1;/p-1/fC42H78NO2.I/h;1h/qm;-1

Appearance: White solid.

Solubility: Soluble in Methanol, DMSO and Ethanol 1:1 (vol:vol): >10mM.

Short Term Storage: +4°C

Long Term Storage: +4°C

Long Shipping: AMBIENT

Use & Stability: Stable for at least 1 year after receipt when stored at +4°C.

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