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AVANTI POLAR LIPIDS , CYGNUS , LARODAN , ADIPOGEN , MYBIOSOURCE , SERVA NORDMARK, BIOWORLD, EDGEBIO , PANREAC APPLICHEM
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Product description: The most prominent members of the interleukin-1 (IL-1) superfamily are IL-1alpha and IL-1beta. They lack a signal peptide and are secreted by an unconventional, endoplasmic reticulum-Golgi-independent mechanism. IL-1alpha was reported to be more widely and constitutively expressed and has intracellular functions, but also acts locally in a membrane-bound form by activating IL-1R1. Additionally, passive release of IL-1alpha upon cell death can trigger a sterile inflammatory response to dying cells. The cleavage of IL-1alpha is not mediated by caspase-1 and is not required for binding to IL-1R1. Recently it has been observed that all activators of the inflammasome NLRP3/NALP3 induce the simultaneous secretion of IL-1alpha and IL-1beta. Although most activators fully rely on the inflammasome for IL-1alpha secretion, some induce the processing and secretion of IL-1alpha in an inflammasome-independent manner.
Alternate Names/Synonyms: Interleukin-1alpha IL-1F1
Product Type: Kit
Specificity: Detects natural and recombinant mouse IL-1alpha (proform and p17 fragment). Does not detect human IL-1alpha or mouse IL-1beta.
Crossreactivity: Mouse
Sensitivity: 9pg/ml
Range: 15.6pg/ml to 1ng/ml
Sample Type: Cell Culture Supernatant, Plasma, Serum
Assay Type: Sandwich
Detection Type: Colorimetric
Short Term Storage: +4°C
Long Term Storage: +4°C
Shipping: BLUE ICE
Use & Stability 12 months after the day of manufacturing. See expiry date on ELISA Kit box.
Handling Advice After standard reconstitution, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles. Plate and reagents should reach room temperature before use.
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