IL-2 (human) (rec.) (untagged)

Product description: Protein. The extracellular domain of human IL-2 (aa 21-153) with a N-terminal Met. Source: E. coli. Endotoxin content: <0.01EU/µg protein (LAL test; Lonza). Lyophilized from sterile 0.1% TFA, 70% acetonitrile. Purity: >95% (SDS-PAGE). Interleukin-2 (IL-2) is a 133 amino acid glycoprotein with one intramolecular disulfide bond and variable glycosylation. It is secreted by activated T cells and induces proliferation and maturation of activated T cells, natural killer cells, and lymphokine activated killer cells. IL-2 also stimulates proliferation of antibody-producing B cells, activates neutrophils, and induces mononuclear cells to secrete IFN-gamma and TNF-alpha and -beta. Moreover, studies have shown that IL-2 is required for activation-induced apoptosis, an important hemeostatic mechanism in the immune system, which is involved in the maintenance of peripheral tolerance to self-antigens.

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