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Product Details | |
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Synonyms | IL-2 Switch-2 (monomeric):Fc Knobs-into-Holes (human) (rec.); Interleukin-2; T Cell Growth Factor; TCGF; IL-2 pH resistant; pH-selective IL-2 Mutein |
Product Type | Protein |
Properties | |
Source/Host | HEK 293 cells |
Sequence |
The extracellular domain of human IL-2 (aa 21-153) (mutant pH-resistant Switch-2 containing mutations T37H, R38L, T41S, F42Y, and K43G) is fused at the C-terminus to the Fc portion of human IgG1 (Knobs-into-Holes technology) (see reference: J.B. Ridgway, et al.; Protein Eng. 9, 617 (1996)). |
Crossreactivity | Human Mouse |
MW | ~45kDa and 28kDa (SDS-PAGE) |
Purity | ≥95% (SDS-PAGE) |
Endotoxin Content | <0.01EU/μg protein (LAL test). |
Concentration | After reconstitution: for 10µg size: 0.1mg/ml for 100µg size: 1mg/ml |
Reconstitution | Reconstitute with 100μl endotoxin-free water. |
Formulation | Lyophilized. Contains PBS. |
Protein Negative Control | |
Other Product Data |
Uniprot link P60568 : IL-2 (human) |
Shipping and Handling | |
Shipping | BLUE ICE |
Short Term Storage | +4°C |
Long Term Storage | -20°C |
Handling Advice | After reconstitution, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles. Centrifuge lyophilized vial before opening and reconstitution. PBS containing at least 0.1% BSA should be used for further dilutions. |
Use/Stability | Stable for at least 6 months after receipt when stored at -20°C. Working aliquots are stable for up to 3 months when stored at -20°C. |
Documents | |
MSDS | Inquire |
Product Specification Sheet | |
Datasheet | ![]() |
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