IL-2 (rat) (rec.) (His)

Product description: Protein. Rat IL-2 (aa 21-155) is fused at the C-terminus to a His-tag. Source: E. coli. Endotoxin content: <1EU/µg protein (LAL test; Lonza). Lyophilized from 0.2µm-filtered solution in PBS (pH 7.4). Purity: >95% (SDS-PAGE). Interleukin-2 (IL-2) is a 133 amino acid glycoprotein with one intramolecular disulfide bond and variable glycosylation. It is secreted by activated T cells and induces proliferation and maturation of activated T cells, natural killer cells and lymphokine activated killer cells. IL-2 also stimulates proliferation of antibody-producing B cells, activates neutrophils and induces mononuclear cells to secrete IFN-gamma and TNF-alpha and -beta. Moreover, studies have shown that IL-2 is required for activation-induced apoptosis, an important hemeostatic mechanism in the immune system, which is involved in the maintenance of peripheral tolerance to self-antigens.

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