IL-33 (human) ELISA Kit

Product description: Interleukin-33 (IL-33; HF-NEV; IL-1F11), a member of the IL-1 family of cytokines, is expressed by many cell types following pro-inflammatory stimulation and is thought to be released on cell lysis. IL-33 affects the various cell types that express membrane ST2, which is selectively expressed by Th2 but not Th1 cells. The ability of IL-33 to target numerous immune cell types, like Th2-like cells, mast cells, and B1 cells, and to induce cytokine and chemokine production underlines its potential in influencing the outcome of a wide range of diseases, such as arthritis, asthma, atopic allergy & anaphylaxis, cardiovascular disease/atherosclerosis, nervous system diseases, and sepsis. In healthy human serum almost no IL-33 could be detected, whereas serum IL-33 levels were significantly increased in chronic active inflammation, like rheumatoid arthritis.

Alternate Names/Synonyms: NF-HEV; Interleukin-33; IL-1F11

Product Type: Kit

Specificity: Detects human IL-33. Does not cross-react with mouse IL-33, human IL-6, human IL-24, human IL-23, human IL-17A or human ST2.

Crossreactivity: Human

Sensitivity: 5pg/ml

Range: 0.016 to 1ng/ml

Sample Type: Cell Culture Supernatant, Plasma, Serum

Assay Type: Sandwich

Detection Type: Colorimetric

Short Term Storage: +4°C

Long Term Storage: +4°C

Shipping: BLUE ICE

Use & Stability 12 months after the day of manufacturing. See expiry date on ELISA Kit box.

Handling Advice After standard reconstitution, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles. Plate and reagents should reach room temperature before use.

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