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5 x 10 µg

Ref. AG-40B-0041-5010
ADIPOGEN LIFE SCIENCES

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Neuf 390.00 351.00 H.T.

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Détails Produit

Product Description: Interleukin-33 (IL-33; HF-NEV; IL-1F11), a member of the IL-1 family of cytokines, is expressed by many cell types following pro-inflammatory stimulation and is thought to be released upon cell lysis. IL33 binds to and signals through ST2 (IL1R1) and its stimulation recruits MYD88, IRAK, IRAK4, and TRAF6, followed by phosphorylation of ERK1(MAPK3)/ERK2(MAPK1), p38(MAPK14), and JNK. The ability of IL-33 to target numerous immune cell types, like Th2-like cells, mast cells, and B1 cells, and to induce cytokine and chemokine production underlines its potential in influencing the outcome of a wide range of diseases, such as arthritis, asthma, atopic allergy & anaphylaxis, cardiovascular disease/atherosclerosis, nervous system diseases, and sepsis.

Alternate Names/Synonyms: Interleukin-33; IL-1F11; NF-HEV

Product type: Protein

Source / Host: E. coli

Sequence: Mouse IL-33 (aa 109-266) is untagged.

Species Crossreactivity: Human, Mouse

Specificity: Binds to mouse and human ST2.

Biological Activity: Activates ST2-dependent NF-kappaB pathway.

Molecular Weight: ~18kDa

TAGs: no Tag

Purity: >95% (SDS-PAGE)

Endotoxin: <0.1EU/µg purified protein (LAL test; Lonza).

Concentration: 0.1mg/ml after reconstitution.

Formulation: Lyophilized. Contains PBS.

Handling Advice: After reconstitution, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles. PBS containing at least 0.1% BSA should be used for further dilutions.

Short Term Storage: +4°C

Long Term Storage: -20°C

Shipping: BLUE ICE

Use & Stability: Stable for at least 6 months after receipt when stored at -20°C. Working aliquots are stable for up to 3 months when stored at -20°C.

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