IL-33R (mouse):Fc (mouse) (rec.)

Product Description: Receptor for interleukin-33 (IL-33). Its stimulation recruits MYD88, IRAK1, IRAK4 and TRAF6 followed by phosphorylation of MAPK3/ERK1 and/or MAPK1/ERK2, MAPK14 and MAPK8 by similarity. Possibly involved in helper T cell function.

Alternate Names/Synonyms: Interleukin-33 Receptor; IL1RL1; DER4; ST2

Product type: Protein

Source / Host: CHO cells

Sequence: The extracellular domain of mouse IL-33R [ST2] (aa 27-342) is fused to the N-terminus of the Fc region of mouse IgG2a.

Species Crossreactivity: Mouse

SBiological Activity: Binds both CD80 (B7-1) and CD86 (B7-2) with high affinity and inhibits CD28 signaling competitively. Kills the target cell completely.

TAGs: Fc

Purity: >98% (SDS-PAGE)

Endotoxin: <0.06EU/µg protein (LAL test; Lonza).

Formulation: Lyophilized from 0.2µm-filtered solution in PBS.

Handling Advice: Avoid freeze/thaw cycles.

Short Term Storage: +4°C

Long Term Storage: -20°C

Shipping: BLUE ICE

Use & Stability: Stable for at least 1 year after receipt when stored at -20°C. Working aliquots are stable for up to 3 months when stored at -20°C.

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