IL-38 (human) (rec.) (His)

Product description: Protein. Human IL-38 (aa 1-152) is fused at the C-terminus to a His-tag. Source: E. coli. Endotoxin content: <1EU/µg purified protein (LAL test; Lonza). Lyophilized from 0.2µm-filtered solution in 55mM TRIS-Cl, pH 8.2, containing 150mM NaCl. Purity: >95% (SDS-PAGE). IL-38 (IL-1F10) mRNA is expressed in heart, placenta, fetal liver, spleen, thymus and tonsil. The expression in a variety of immune tissues and similarity to IL-1Ra suggest a role of IL-1F10 in the inflammatory response. It has been reported that removal of the N-terminus domain of the interleukins of the IL-1F family such as IL-1F5 / 6 / 8 or 9 (also called IL-36Ra, IL-36alpha, IL-36beta or IL-36gamma) is important to increase their biological activity. Recently it has been shown that IL-38 is N-terminally processed and secreted by apoptotic cells. Released processed IL-38 (20-152) binds to the receptor Interleukin-1 receptor accessory protein-like 1 (IL1RAPL1; TIGIRR-2) at the surface of macrophages. Processed IL-38-activated IL1RAPL1 reduces the production of IL-6 leading to inflammation attenuation.

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