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50 µg

Ref. SBB-PS0002-C050
South Bay Bio

photos non contractuelles

Neuf 310.00 H.T.


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Détails Produit

Product Description: ISG15 (Interferon Stimulated Gene, 15kDa) is a ubiquitin-like modifier which initiates innate immune response by activating RIG-I signaling, stimulating NK-cell proliferation, inhibiting viral budding and acting as an IFNgamma-inducing cytokine. ISG15 contains two tandem ubiquitin homology domains and is cross-reactive with alpha-Ubiquitin antibodies. Conjugation of ISG15 to a substrate protein occurs through a ubiquitin like cascade via an E1 (UBE1L), E2 (UbcH8/UBE2L6) and E3 (not yet discovered.) Deconjugation normally occurs via UBP43 (USP18), however there are several viral proteases that are able to hydrolyze ISG15 conjugates in order to evade immune response. These include the OTU-containing protease of Crimean-Congo Hemorrhagic Fever nairovirus and the Papain-Like Protease (PLPro) of the SARS coronavirus.

Alternate Names/Synonyms: ISG15 Ubiquitin-like Modifier; G1P2; IFI15; IP17; UCRP

Product type: Protein

Source / Host: E. coli

Sequence: Human ISG15 (aa1-157) conjugated at the C-terminus to a quenched Rhodamine 110 dye.

Species Crossreactivity: Human

Molecular Weight: ~18kDa

Labels - Conjugates: Rhodamine

Purity: >97% (LCMS)

Concentration: Lot dependent.

Formulation: Liquid. In 50mM MES pH 6.0, 100mM sodium chloride, 10% glycerol.

Handling Advice: Aliquot to avoid freeze/thaw cycles. Protect from light.

Short Term Storage: -80°C

Long Term Storage: -80°C

Shipping: DRY ICE

Use & Stability: Stable for at least 1 year after receipt when stored at -80°C.

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